, if a client is obtaining clonidine hydrochloride and also taking tricyclic antidepressants the hypotensive effects of clonidine could be reduced.


Clonidine Bipolar.

Because of a possibility for additive effects such as bradycardia and AV block, caution is required in patients obtaining clonidine concomitantly with representatives recognized to have an effect on sinus node function or AV nodal transmission (e. g. digitalis, calcium network blockers and also beta-blockers).

Generic Clonidine.

Usage caution when clonidine hydrochloride extended-release tablet computers are provided concomitantly with antihypertensive drugs, due to the potential for additive pharmacodynamic impacts (e. g. hypotension, syncope) [see Precautions and also warnings (5.

Clonidine Bipolar Disorder.

Pregnancy Category C: Oral administration of clonidine hydrochloride to expecting rabbits throughout the duration of embryo/fetal organogenesis at doses of approximately 80 mcg/kg/day (about 3 times the oral maximum suggested everyday dose [MRHD] of 0.4 mg/day on a mg/m2 basis) produced no proof of teratogenic or embryotoxic capacity. In pregnant rats, nevertheless, doses as low as 15 mcg/kg/day (1/3 the MRHD on a mg/m2 basis) were linked with enhanced tractions in a study in which dams were dealt with constantly from 2 months before breeding and throughout pregnancy. Enhanced resorptions were not linked with therapy at the very same or at greater dosage degrees (approximately 3 times the MRHD) when therapy of the dams was restricted to gestation days 6-15. Boosts in resorptions were noted in both rats and computer mice at 500 mcg/kg/day (10 as well as 5 times the MRHD in rats and mice, specifically) or greater when the pets were treated on gestation days 1-14; 500 mcg/kg/day was the most affordable dosage employed in this study. No appropriate as well as well-controlled research studies have been carried out in expectant ladies. Considering that pet recreation researches are not consistently predictive of human feedback, this medication should not be utilized during maternity unless plainly required.

  • Clonidine